Once upon a time, I attempted to create a web-based one-stop-shop for global poverty relief called the Maximin Project. Drawing on aspects of that experience, I show that although some existing ways of rating and recommending charities are significantly better than others, there remain certain challenges that need to be overcome. Specifically, I argue that the emerging Effective Altruism movement, with its emphasis on measurable effectiveness, runs the risk of neglecting a whole range of projects that are necessary for a (...) well-rounded approach to human development. I briefly model an alternative virtue-based approach that calls on the personal insight of individual researchers and practitioners in addition to the more directly experimental approach of organizations like GiveWell. (shrink)

In this paper, we discuss a team-taught, debate-style Philosophy of Religion course we designed and taught at The Ohio State University. Rather than tackling the breadth of topics traditionally subsumed under the umbrella of Philosophy of Religion, this course focused exclusively on the nuances of the atheism-theism debate, with the instructors openly identifying as atheist or theist, respectively. After discussing the motivations for designing and teaching such a course, we go on to detail its content and structure. We then examine (...) various challenges and hurdles we faced, as well as some benefits we encountered along the way. Next, we discuss some informal data collected from the students enrolled in the course, some of which suggest some rather surprising outcomes. We conclude with some considerations of the applicability of this style of teaching to other philosophical debates. (shrink)

Somatic mutations arising in human skin cancers are heterogeneously distributed across the genome, meaning that certain genomic regions (e.g., heterochromatin or transcription factor binding sites) have much higher mutation densities than others. Regional variations in mutation rates are typically not a consequence of selection, as the vast majority of somatic mutations in skin cancers are passenger mutations that do not promote cell growth or transformation. Instead, variations in DNA repair activity, due to chromatin organization and transcription factor binding, have been (...) proposed to be a primary driver of mutational heterogeneity in melanoma. However, as discussed in this review here, recent studies indicate that chromatin organization and transcription factor binding also significantly modulate the rate at which UV lesions form in DNA. The authors propose that local variations in lesion susceptibility may be an important driver of mutational hotspots in melanoma and other skin cancers, particularly at binding sites for ETS transcription factors. (shrink)

This introduction to the Common Knowledge symposium titled “Comparative Relativism” outlines a variety of intellectual contexts where placing the unlikely companion terms comparison and relativism in conjunction offers analytical purchase. If comparison, in the most general sense, involves the investigation of discrete contexts in order to elucidate their similarities and differences, then relativism, as a tendency, stance, or working method, usually involves the assumption that contexts exhibit, or may exhibit, radically different, incomparable, or incommensurable traits. Comparative studies are required to (...) treat their objects as alike, at least in some crucial respects; relativism indicates the limits of this practice. Jensen argues that this seeming paradox is productive, as he moves across contexts, from Lévi-Strauss's analysis of comparison as an anthropological method to Peter Galison's history of physics, and on to the anthropological, philosophical, and historical examples offered in symposium contributions by Barbara Herrnstein Smith, Eduardo Viveiros de Castro, Marilyn Strathern, and Isabelle Stengers. Comparative relativism is understood by some to imply that relativism comes in various kinds and that these have multiple uses, functions, and effects, varying widely in different personal, historical, and institutional contexts that can be compared and contrasted. Comparative relativism is taken by others to encourage a “comparison of comparisons,” in order to relativize what different peoples—say, Western academics and Amerindian shamans—compare things “for.” Jensen concludes that what is compared and relativized in this symposium are the methods of comparison and relativization themselves. He ventures that the contributors all hope that treating these terms in juxtaposition may allow for new configurations of inquiry. (shrink)

BackgroundCritical public health measures implemented to mitigate the spread of the novel coronavirus disease (COVID-19) pandemic have disrupted health research worldwide, including HIV prevention research. While general guidance has been issued for the responsible conduct of research in these challenging circumstances, the contours of the dueling COVID-19 and HIV/aids pandemics raise some critical ethical issues for HIV prevention research. In this paper, we use the recently updated HIV Prevention Trials Network (HPTN) Ethics Guidance Document (EGD) to situate and analyze key (...) ethical challenges related to the conduct of HIV prevention research during the COVID-19 pandemic as well as identify potential areas for refinement of the guidance document based on this unprecedented state of affairs.Main bodyNecessary actions taken for HIV prevention research studies due to the COVID-19 pandemic involve an array of ethical issues including those related to: (1) risk mitigation; (2) behavior change; (3) compounding vulnerability; (4) community engagement; (5) trial reopening; and 6) shifting research priorities.ConclusionsIn the context of the dueling HIV and COVID-19 global pandemics, research teams and sponsors must be nimble in responding to the rapidly changing environment by being sensitive to the associated ethical issues. The HTPN EGD provides a rich set of tools to help identify, analyze and address many of these issues. At the same time, future refinements of the HPTN EGD and other research ethics guidance could be strengthened by providing explicit advice regarding the ethical issues associated with disrupted research and the reopening of studies. In addition, additional consideration should be given to appropriately balancing domains of risk (e.g., physical versus social), addressing the vulnerability of research staff and community partners, and responding to un-anticipatable ancillary care needs of participants and communities. Appropriately addressing these issues will necessitate conceptual work, which would benefit from the careful documentation of the actual ethical issues encountered in research, the strategies implemented to overcome them, and their success in doing so. Throughout all of these efforts, it is critical to remember that the HIV pandemic not be forgotten in the rush to deal with the COVID-19 pandemic. (shrink)

Past research has found that skin colouration, particularly facial redness, influences the perceived health and emotional state of target individuals. In the current work, we explore several extensions of this past research. In Experiment 1, we manipulated facial redness incrementally on neutral and angry faces and had participants rate each face for anger and health. Different red effects emerged, as perceived anger increased in a linear manner as facial redness increased. Health ratings instead showed a curvilinear trend, as both extreme (...) paleness and redness were rated as less healthy than moderate levels of red. Experiment 2 replicated and extended these findings by manipulating the masculinity of both angry and neutral faces that varied in redness. The results found the effect of red on perceived anger and health was moderated by masculine face structure. Collectively, these results show that facial redness has context dependent effects that vary based on facial expression, appearance, and differentially impact ratings of emotional states and health. (shrink)

In ancient times, when persuasion played the role of public force, eloquence was necessary. Of what use would it be today, when public force has replaced persuasion. One needs neither art nor metaphor to say such is my pleasure. Jean Jacques Rousseau.

Emotion expressions convey valuable information about others’ internal states and likely behaviours. Accurately identifying expressions is critical for social interactions, but so is perceiver confidence when decoding expressions. Even if a perceiver correctly labels an expression, uncertainty may impair appropriate behavioural responses and create uncomfortable interactions. Past research has found that perceivers report greater confidence when identifying emotions displayed by cultural ingroup members, an effect attributed to greater perceptual skill and familiarity with own-culture than other-culture faces. However, the current research (...) presents novel evidence for an ingroup advantage in emotion decoding confidence across arbitrary group boundaries that hold culture constant. In two experiments using different stimulus sets participants not only labeled minimal ingroup expressions more accurately, but did so with greater confidence. These results offer novel evidence that ingroup advantages in emotion decoding confidence stem partly from social-cognitive processes. (shrink)

How might we think about relationships between philosophy as a way of life and the domain of the political? Or, since there are clearly, and importantly, multiple understandings of philosophy as a way of life and multiple aspects of the domain of the political, let me put my question somewhat more narrowly as: How might we think about relationships between the kind of ongoing work of self-cultivation and self-transformation which has been at least one continuing dimension of philosophy in the (...) West from its beginning and the existence, realities, and responsibilities of social life? (shrink)

If the mental is subject to indeterminacy, does this rule out the possibility of psychophysical laws? One might think so. However, Jaegwon Kim has argued for the existence of a kind of psychophysical law that is not obviously susceptible to problems posed by indeterminacy. I begin by introducing a weak and relatively uncontroversial indeterminacy thesis. Then, by appealing to constraints on theories of strong supervenience and to general considerations about the nature of indeterminacy, I argue that even Kim’s laws cannot (...) accommodate indeterminacy. The result is an argument against the possibility of Kim‐Style psychophysical laws. (shrink)

Transition to Real Analysis with Proof provides undergraduate students with an introduction to analysis including an introduction to proof. The text combines the topics covered in a transition course to lead into a first course on analysis. This combined approach allows instructors to teach a single course where two were offered. The text opens with an introduction to basic logic and set theory, setting students up to succeed in the study of analysis. Each section is followed by graduated exercises that (...) both guide and challenge students. The author includes examples and illustrations that appeal to the visual side of analysis. The accessible structure of the book makes it an ideal refence for later years of study or professional work. (shrink)

The history of economic thought has always attracted some of the brightest minds in the discipline. These chroniclers of development have helped form our current views, and it is no surprise that many among them have been at the forefront of new movements in the history of ideas. This notable collection summarizes the work of these key historians of economics and attempts to quantify their impact. Some of the writers covered, such as Friedrich Hayek and Joan Robinson, are already assured (...) of their place among the greatest economists of the twentieth century, but the collection also stresses the influence of those still active in shaping our perceptions - including Mark Blaug, Samuel Hollander and Donald Winch. Written by an impressive roster of contributors, many of whom are themselves well-known in the history of economic thought, this key book features writings from John Creedy, Roger Blackhouse and Neil De Marchi, as well as the editors of the collection as a whole, Warren J. Samuels and Steven Medema. (shrink)

The transactivation response‐DNA binding protein of 43 kDa (TDP‐43) is an aggregation‐prone nucleic acid‐binding protein linked to the etiology of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD). These conditions feature the accumulation of insoluble TDP‐43 aggregates in the neuronal cytoplasm that lead to cell death. The dynamics between cytoplasmic and nuclear TDP‐43 are altered in the disease state where TDP‐43 mislocalizes to the cytoplasm, disrupting Nuclear Pore Complexes (NPCs), and ultimately forming large fibrils stabilized by the C‐terminal prion‐like (...) domain. Here, we review three emerging and poorly understood aspects of TDP‐43 biology linked to its aggregation. First, how post‐translational modifications in the proximity of TDP‐43 N‐terminal domain (NTD) promote aggregation. Second, how TDP‐43 engages FG‐nucleoporins in the NPC, disrupting the pore permeability and function. Third, how the importin α/β heterodimer prevents TDP‐43 aggregation, serving both as a nuclear import transporter and a cytoplasmic chaperone. (shrink)

This book demonstrates the vital connection between language and gesture, and why it is critical for research on second language acquisition to take into account the full spectrum of communicative phenomena. The study of gesture in applied linguistics is just beginning to come of age. This edited volume, the first of its kind, covers a broad range of concerns that are central to the field of SLA. The chapters focus on a variety of second-language contexts, including adult classroom and naturalistic (...) learners, and represent learners from a variety of language and cultural backgrounds. Gesture: Second Language Acquisition and Classroom Research is organized in five sections: Part I, Gesture and its L2 Applications, provides both an overview of gesture studies and a review of the L2 gesture research. Part II, Gesture and Making Meaning in the L2, offers three studies that all take an explicitly sociocultural view of the role of gesture in SLA. Part III, Gesture and Communication in the L2, focuses on the use and comprehension of gesture as an aspect of communication. Part IV, Gesture and Linguistic Structure in the L2, addresses the relationship between gesture and the acquisition of linguistic features, and how gesture relates to proficiency. Part V, Gesture and the L2 Classroom, considers teachers’ gestures, students’ gestures, and how students’ interpret teachers’ gestures. Although there is a large body of research on gesture across a number of disciplines including anthropology, communications, psychology, sociology, and child development, to date there has been comparatively little investigation of gesture within applied linguistics. This volume provides readers unfamiliar with L2 gesture studies with a powerful new lens with which to view many aspects of language in use, language learning, and language teaching. (shrink)

Mark Blaug's contributions to economics were many and significant. This essay provides a review of Mark Blaug: Rebel with Many Causes, edited by Marcel Boumans and Matthias Klaes, which collects papers from a set of conferences organized in Blaug's memory.

ABSTRACT Ken Hanly's recent article in this Journal (Vol. 9, No. 1, 1992) takes issue with Ronald Coase's approach to resolving problems of externalities, as set forth in his classic paper ‘The Problem of Social Cost’. I argue that Hanly's discussion of Coase misinterprets or inappropriately rejects certain aspects of Coase's analysis, specifically, with regard to the reciprocal nature of externalities and the economic role of government. The resolution of externality problems is presented as an issue of selective normative choice (...) as to whose interests are to count; neither efficiency nor morality claims are uniquely dispositive of the issue. (shrink)

If the mental is subject to indeterminacy, does this rule out the possibility of psychophysical laws? One might think so. However, Jaegwon Kim has argued for the existence of a kind of psychophysical law that is not obviously susceptible to problems posed by indeterminacy. I begin by introducing a weak and relatively uncontroversial indeterminacy thesis. Then, by appealing to constraints on theories of strong supervenience and to general considerations about the nature of indeterminacy, I argue that even Kim’s laws cannot (...) accommodate indeterminacy. The result is an argument against the possibility of Kim‐Style psychophysical laws. (shrink)

Rooting, defined as a spectator’s demonstrative encouragement of a contestant’s effort, ideally has the morally positive aspects of benevolent concern and helpfulness but in practice strains against reasonable standards of conduct by being rude, excessively biased, exploitative, fanatical, and superstitious. Rooting may activate an atavistic, morally cogent sense of fighting for one’s group that is at odds with the universalism of civilized morality. The ‘merely play’ excuse can cut both ways, deflecting moral objections but also removing moral credit from rooting. (...) Although rooting is often not humane, humane rooting can occur and is supported by humane commentary by sports participants, broadcasters, and journalists. Humane rooting supports the premise of benevolence theories (Mengzi, Hutcheson) that morally ideal benevolence has a foothold in an innate general benevolence – seen in this area especially in benevolence toward efforts. Being partisan, excited, and demonstrative, rooters cannot perfectly embody ‘universal calm benevolence’, but they can consciously minimize the inhumane aspects of rooting and achieve a more fully prosocial satisfaction. (shrink)

Word usage and behavior show that most people think of music as a distinct category of valuable experience, yet music lovers are known to have widely different ideas of what music offers. Some love its power to express or arouse emotions; some love the immediate sensuous-kinetic pleasure of tone and beat; some find a compelling sense of individual or communal identity in it; some are caught by the puzzle-solving interest of its compositional designs. Most will agree, nonetheless, that music is (...) wonderful in a musical way—an expresser of emotions not interchangeable with other expressive means, a source of pleasure not interchangeable with other sources, and so on—which seems to indicate that an essential musicality.. (shrink)

"To my knowledge, there has never [before] been a volume that analyzes, in one place, the actual language of science--those elements of thinking that are acknowledged to be the basis of scientific thought. . . . [Thus] this is a very important book, contributing to several fields: science, education, rhetoric, medicine, and perhaps even philosophy. . . . Darian's erudition is truly astonishing." --Celest A. Martin, Associate Professor, College Writing Program, University of Rhode Island From astronomy to zoology, the practice (...) of science proceeds from scientific ways of thinking. These patterns of thought, such as defining and classifying, hypothesizing and experimenting, form the building blocks of all scientific endeavor. Understanding how they work is therefore an essential foundation for everyone involved in scientific study or teaching, from elementary school students to classroom teachers and professional scientists. In this book, Steven Darian examines the language of science in order to analyze the patterns of thinking that underlie scientific endeavor. He draws examples from university science textbooks in a variety of disciplines, since these offer a common, even canonical, language for scientific expression. Darian identifies and focuses in depth on nine patterns--defining, classifying, using figurative language, determining cause and effect, hypothesizing, experimenting, visualizing, quantifying, and comparing--and shows how they interact in practice. He also traces how these thought modes developed historically from Pythagoras through Newton. (shrink)